At the forefront of medical breakthroughs

Research with potential to transform healthcare and to benefit the Irish and global population

GMI’s mission is to build a high-quality genomic database which will include data from approximately 10% of the Irish population including patients with various disease conditions and participants from the general population.

We are using multiple, advanced, genomic techniques to generate this data including:

  • Next-generation sequencing
  • Gene expression and methylation profiling
  • Structural genome variation discovery
  • Metabolite screening
  • This information, linked to comprehensive phenotype data, will help in the development of new diagnostic techniques and in understanding cell and system biology with the aim to discover better disease treatments. Our highly-skilled dedicated team of scientists work in multi-disciplinary groups, focusing on clinical research and analysis, laboratory sciences and bioinformatics. Together with our partners and volunteers, GMI is putting Ireland at the forefront of genomic research.

    Illumina NovaSeq 6000
    Illumina NovaSeq 6000
    The NovaSeq6000 is the most advanced high-throughput sequencing system in the world, with the capacity to sequence 40 whole genomes in 48 hours. GMI owns several NovaSeqs making the company the largest genomics facility in Ireland and amongst the top in Europe.
    Thermo Scientific GeneTitan
    Thermo Scientific GeneTitan
    The GeneTitan™ instrument together with the Precision Medicine Research Array allows us to screen for greater than 900,000 SNPs. Among the Arrays contents there are 10,000 variants in ACMG genes, 34,000 markers of ClinVar content and comprehensive coverage of HLA regions and pharmacogenomics content.
    Nanopore Technologies GridION X5
    Nanopore Technologies GridION X5
    The Gridion is a compact benchtop system used for long read sequencing of DNA and RNA. This systems allows for real time analysis of up to 5 MinION flow cells.
    Autogen FLEX STAR
    Autogen FLEX STAR
    The FlexStar is a fully automated DNA extraction platform which can be used with various sample types including up to 5mls of blood. This system utilises Qiagen FlexiGene Chemistry to extract high-quality genomic DNA.
    Hamilton Microlab STAR
    Hamilton Microlab STAR
    The Hamilton Microlab STAR is an advanced liquid handling robotics system providing high-throughput, precise sample pipetting.